Evaluation of The Topical Effect of Calendula Officinalis Oral Paste in The Treatment of Recurrent Aphthous Stomatitis: A Randomized Double-Blind Controlled Trial
DOI:
https://doi.org/10.15218/edj.2025.20Keywords:
Recurrent Aphthous Stomatitis, Calendula Officinalis, Inflammation, IrisinAbstract
Background and Objectives: Recurrent aphthous stomatitis is the most common recurrent ulceration in the oral mucosa. The anti-inflammatory and wound-healing properties of Calendula officinalis make it a medicinal plant. This study aims to evaluate Calendula Officinalis 10% and 15% oral pastes compared with triamcinolone acetonide 0.1% and placebo oral pastes, and to evaluate salivary Irisin as an inflammatory marker before and after treatment.
Materials and Methods: A randomised, double-anonymised case-control clinical study included 60 patients with minor recurrent aphthous stomatitis (age range: 16-50 years. Patients used (Calendula officinalis in 10 % and 15 %, triamcinolone acetonide 0.1 % and placebo) oral pastes for one week. Clinical observation for (ulcer size, pain and erythema) was done on days (0, 4 and 7). Salivary irisin level was measured before and after treatment.
Results: Significant differences were noted by topical treatment with 10% and 15% calendula officinalis and triamcinolone acetonide 0.1% oral pastes at the 4th and 7th day in reducing ulcer size, erythema and pain (P<0.001). The most significant reduction was achieved with 15% Calendula officinalis on the 4th day. A significant difference in salivary irisin levels was observed before and after treatment with all four group pastes (P<0.001).
Conclusion: Calendula officinalis 15% oral paste showed a significant effect on reducing ulcer size, pain, and erythema in Recurrent Aphthous Stomatitis patients over 4 days.
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Copyright (c) 2025 Asma Qasim Rahman, Reiadh Kamal Al-Kamali, Kawa Fareq Dizaye, Nozad Rashid Hussein, Rebin Ali Mohammedammen (Author)
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