Impact of diabetes mellitus on dental implants: A cross sectional controlled clinical study.
DOI:
https://doi.org/10.15218/edj.2023.22Keywords:
Bacteriology, Diabetes mellitus, Interleukin 6, Osseointegration, PeriimplantitisAbstract
Background and objective: After osseointegration the long-term success of dental implants is
determined by the maintenance of the peri-implant soft tissue and bone level. This study
evaluates the impact of Diabetes mellitus on dental implants in diabetic patients and compare it with that of nondiabetic patients.
Patients and methods: Thirty diabetic patients and thirty controlled subjects rehabilitated
with dental implants were included in this study. The duration of implant treatment is (1-7)
years, and dental implant status between both groups was compared using Immunohistochemistry for analyzing Interleukin 6 in peri-implant crevicular fluid, bacteriology, radiology,
and clinically by measuring gingival sulcus depth, bleeding on probing, gingival recession,
presence of suppuration and mobility. The statistical package for the social sciences program
(SPSS, version 28) was used for data analysis.
Results: Diabetic patients show a Statistically significant difference to non diabetic subjects in
the level of interleukin 6 with (P value 0.004), Culture and sensitivity with (P value 0.003), Peri
-implant bone loss in mesial and distal sides of the implant with P values 0.006 and 0.002
respectively, and also, in gingival recession with (P value 0.017). while the difference was not
significant in gingival sulcus depth P value0.220, bleeding on probing P value0.550, implant
suppuration P value 0.999, and mobility P value 0.999.
References
M. Viswambaran KV. Health and Research. 2020;1
(2):2–4.
Hwang D, Wang HL. Medical contraindications to
implant therapy: Part II: relative contraindications. Implant Dent. 2007;16(1):13–23.
Moraschini V, Barboza ESP, Peixoto GA. The impact of diabetes on dental implant failure: a systematic review and meta-analysis. Int J Oral Maxillofac Surg [Internet]. 2016;45(10):1237– 45.
Available from: http://dx.doi.org/10.1016/
j.ijom.2016.05.019
de Araújo Nobre M, Maló P, Gonçalves Y, Sabas A,
Salvado F. Dental implants in diabetic patients:
retrospective cohort study reporting on implant
survival and risk indicators for excessive marginal
bone loss at 5 years. J Oral Rehabil. 2016;43
(11):863–70.
Turkyilmaz I. One-year clinical outcome of dental
implants placed in patients with type 2 diabetes
mellitus: A case series. Implant Dent. 2010;19
(4):323–9.
Jiang X, Zhu Y, Liu Z, Tian Z, Zhu S. Association
between diabetes and dental implant complications: a systematic review and meta-analysis. Acta Odontol Scand [Internet]. 2021;79(1):9–18.
Available from: https://
doi.org/10.1080/00016357.2020.1761031
Al Zahrani S, Al Mutairi AA. Stability and bone loss
around submerged and non-submerged implants
in diabetic and non-diabetic patients: a 7-year
follow-up. Braz Oral Res. 2018;32:e57.
Chambrone L, Palma LF. Current status of dental
implants survival and peri-implant bone loss in
patients with uncontrolled type-2 diabetes mellitus. Curr Opin Endocrinol Diabetes Obes. 2019;26
(4):219–22.
Oikarinen K, Raustia AM, Hartikainen M. General
and local contraindications for endosseal implants ‐ an epidemiological panoramic radiograph
study in 65‐year‐old subjects. Community Dent
Oral Epidemiol. 1995;23(2):114–8.
Al Zahrani S, Al Mutairi AA. Crestal Bone Loss
Around Submerged and Non-Submerged Dental
Implants in Individuals with Type-2 Diabetes
Mellitus: A 7-Year Prospective Clinical Study. Med
Princ Pract. 2019;28(1):75–81. 19
Javed F, Romanos GE. Impact of Diabetes Mellitus and Glycemic Control on the Osseointegration
of Dental Implants: A Systematic Literature Review. J Periodontol. 2009;80(11):1719–30.
Al-Askar M, Ajlan S, Alomar N, Al-Daghri NM.
Clinical and Radiographic Peri-Implant Parameters and Whole Salivary Interleukin-1β and Interleukin-6 Levels among Type-2 Diabetic and Nondabetic Patients with and without Peri-Implantitis.
Med Princ Pract. 2018;27(2):133–8.
Rakic M, Lekovic V, Nikolic-Jakoba N, Vojvodic
D, Petkovic-Curcin A, Sanz M. Bone loss biomarkers associated with peri-implantitis. A
cross-sectional study. Clin Oral Implants Res.
;24(10):1110–6.
Abreu MH, Bianchini MA, Magini RS, Rösing CK.
Clinical and radiographic evaluation of periodontal and peri-implant conditions in patients with
implant-supported prosthesis. Acta Odontol Latinoam. 2007;20(2):87–95.
Lindhe J, Meyle J. Peri-implant diseases: Consensus Report of the Sixth European Workshop
on Periodontology. J Clin Periodontol. 2008;35
(SUPPL. 8):282–5. 16. Bessa Rebelo MA, de Queiroz AC. Gingival Indices: State of Art. Gingival Dis
- Their Aetiol Prev Treat. 2011;
Newman Takei Henry H. Klokkevold Perry R.
MG. Newman and Carranza’s Clinical Periodontology Thirteenth Edition. J Chem Inf Model.
;53(9):1689–99.
Isola G, Lo Giudice A, Polizzi A, Alibrandi A, Murabito P, Indelicato F. Identification of the different salivary Interleukin-6 profiles in patients with
periodontitis: A cross-sectional study. Arch Oral
Biol [Internet]. 2021;122(September
:104997. Available from: https://
doi.org/10.1016/j.archoralbio.2020.104997 19.
He Q, Mu Z, Shrestha A, Wang C, Wang S, Tang
H, et al. Development of a rat model for type 2
diabetes mellitus peri-implantitis: A preliminary
study. Oral Dis. 2021;(March 2020):1–11.
Radaelli K, Alberti A, Corbella S, Francetti L. The
Impact of Peri-Implantitis on Systemic Diseases
and Conditions: A Review of the Literature. Int J
Dent. 2021;2021.
He Q, Mu Z, Shrestha A, Wang C, Wang S, Tang
H, et al. Development of a rat model for type 2
diabetes mellitus peri-implantitis: A preliminary
study. Oral Dis. 2021;(March 2020):1–11. 20.
Radaelli K, Alberti A, Corbella S, Francetti L. The
Impact of Peri-Implantitis on Systemic Diseases
and Conditions: A Review of the Literature. Int J
Dent. 2021;2021.
Radaelli K, Alberti A, Corbella S, Francetti L. The
Impact of Peri-Implantitis on Systemic Diseases
and Conditions: A Review of the Literature. Int J
Dent. 2021;2021.
Zhou SY, Duan XQ, Hu R, Ouyang XY. Effect of
non-surgical periodontal therapy on serum levels
of TNF-a, IL-6 and C-reactive protein in periodontitis subjects with stable coronary heart disease.
Chin J Dent Res. 2013;16(2):145–51.
Yeh HC, Lu JJ, Chang SC, Ge MC. Identification
of microbiota in peri-implantitis pockets by matrix-assisted laser desorption/ionization time-offlight mass spectrometry. Sci Rep [Internet].
;9(1):1–9. Available from: http://
dx.doi.org/10.1038/s41598-018-37450-5
Celakovsky P, Kalfert D, Smatanova K, Tucek L,
Cermakova E, Mejzlik J, et al. Bacteriology of deep
neck infections: Analysis of 634 patients. Aust
Dent J. 2015;60(2):212–5.
Fu JH, Wang HL. Breaking the wave of periimplantitis. Periodontol 2000. 2020;84(1):145–60.
Lagunov VL, Sun J, George R. Evaluation of biologic implant success parameters in type 2 diabetic glycemic control patients versus health patients: A meta-analysis. J Investig Clin Dent.
;10(4):e12478.
Al Amri MD, Kellesarian SV, Al-Kheraif AA, Malmstrom H, Javed F, Romanos GE. Effect of oral hygiene maintenance on HbA1c levels and periimplant parameters around immediatelyloaded
dental implants placed in type-2 diabetic patients: 2 years follow-up. Clin Oral Implants Res.
;27(11):1439–43.
Alsahhaf A, Alshiddi IF, Alshagroud RS, Al-Aali
KA, Vohra F, Abduljabbar T. Clinical and radiographic indices around narrow diameter implants
placed in different glycemic-level patients. Clin
Implant Dent Relat Res. 2019;21(4):621–6.
Jepsen S, Caton JG, Albandar JM, Bissada NF,
Bouchard P, Cortellini P, et al. Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of
workgroup 3 of the 2017 World Workshop on the
Classification of Periodontal and Peri-Implant
Diseases and Conditions. J Clin Periodontol.
;45(December 2017):S219–29.
Jung CY, Kim KC, Sung YS. Ce Pt E Us Cr Ip T Pt E
Us Cr. 2019;1–24.
Sanz M, Ceriello A, Buysschaert M, Chapple I,
Demmer RT, Graziani F, et al. Scientific evidence
on the links between periodontal diseases and
diabetes: Consensus report and 21 guidelines of
the joint workshop on periodontal diseases and
diabetes by the International Diabetes Federation
and the European Federation of Periodontology. J
Clin Periodontol. 2018;45(2):138–49.
Albandar JM, Susin C, Hughes FJ. Manifestations
of systemic diseases and conditions that affect
the periodontal attachment apparatus: Case definitions and diagnostic considerations. J Clin Periodontol. 2018;45(October 2017):S171–89.
Sghaireen MG, Alduraywish AA, Chandan Srivastava K, Shrivastava D, Patil SR, Habib S Al, et al.
Comparative evaluation of dental implant failure
among healthy and well-controlled diabetic patients—a 3-year retrospective study. Int J Environ
Res Public Health. 2020;17(14):1–10.
Andrade CAS, Paz JLC, de Melo GS, Mahrouseh
N, Januário AL, Capeletti LR. Survival rate and peri
-implant evaluation of immediately loaded dental
implants in individuals with type 2 diabetes mellitus: a systematic review and meta-analysis. Clin
Oral Investig [Internet]. 2022;26(2):1797–810.
Available from: https://doi.org/10.1007/s00784-
-04154-6
Ansari Y Al, Shahwan H, Chrcanovic BR. Diabetes
Mellitus and Dental Implants: A Systematic Review and Meta-Analysis. Materials (Basel).
;15(9).
Erdogan Ö, Uçar Y, Tatli U, Sert M, Benlidayi ME,
Evlice B. A clinical prospective study on alveolar
bone augmentation and dental implant success in
patients with type 2 diabetes. Clin Oral Implants
Res. 2015;26(11):1267–75.
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