Impact of diabetes mellitus on dental implants: A cross sectional controlled clinical study.

Authors

  • Rezhna Muhammed Hamad-Ameen Directorate of health-Erbil / Oral and maxillofacial surgery department- Rizgary teaching hospital- Erbil, Iraq.
  • Othman Abu-Bakr Omer Department of Oral and Maxillofacial Surgery, College of Dentistry, Hawler Medical University, Erbil, Iraq.

DOI:

https://doi.org/10.15218/edj.2023.22

Keywords:

Bacteriology, Diabetes mellitus, Interleukin 6, Osseointegration, Periimplantitis

Abstract

Background and objective: After osseointegration the long-term success of dental implants is
determined by the maintenance of the peri-implant soft tissue and bone level. This study
evaluates the impact of Diabetes mellitus on dental implants in diabetic patients and compare it with that of nondiabetic patients.
Patients and methods: Thirty diabetic patients and thirty controlled subjects rehabilitated
with dental implants were included in this study. The duration of implant treatment is (1-7)
years, and dental implant status between both groups was compared using Immunohistochemistry for analyzing Interleukin 6 in peri-implant crevicular fluid, bacteriology, radiology,
and clinically by measuring gingival sulcus depth, bleeding on probing, gingival recession,
presence of suppuration and mobility. The statistical package for the social sciences program
(SPSS, version 28) was used for data analysis.
Results: Diabetic patients show a Statistically significant difference to non diabetic subjects in
the level of interleukin 6 with (P value 0.004), Culture and sensitivity with (P value 0.003), Peri
-implant bone loss in mesial and distal sides of the implant with P values 0.006 and 0.002
respectively, and also, in gingival recession with (P value 0.017). while the difference was not
significant in gingival sulcus depth P value0.220, bleeding on probing P value0.550, implant
suppuration P value 0.999, and mobility P value 0.999.

References

M. Viswambaran KV. Health and Research. 2020;1

(2):2–4.

Hwang D, Wang HL. Medical contraindications to

implant therapy: Part II: relative contraindications. Implant Dent. 2007;16(1):13–23.

Moraschini V, Barboza ESP, Peixoto GA. The impact of diabetes on dental implant failure: a systematic review and meta-analysis. Int J Oral Maxillofac Surg [Internet]. 2016;45(10):1237– 45.

Available from: http://dx.doi.org/10.1016/

j.ijom.2016.05.019

de Araújo Nobre M, Maló P, Gonçalves Y, Sabas A,

Salvado F. Dental implants in diabetic patients:

retrospective cohort study reporting on implant

survival and risk indicators for excessive marginal

bone loss at 5 years. J Oral Rehabil. 2016;43

(11):863–70.

Turkyilmaz I. One-year clinical outcome of dental

implants placed in patients with type 2 diabetes

mellitus: A case series. Implant Dent. 2010;19

(4):323–9.

Jiang X, Zhu Y, Liu Z, Tian Z, Zhu S. Association

between diabetes and dental implant complications: a systematic review and meta-analysis. Acta Odontol Scand [Internet]. 2021;79(1):9–18.

Available from: https://

doi.org/10.1080/00016357.2020.1761031

Al Zahrani S, Al Mutairi AA. Stability and bone loss

around submerged and non-submerged implants

in diabetic and non-diabetic patients: a 7-year

follow-up. Braz Oral Res. 2018;32:e57.

Chambrone L, Palma LF. Current status of dental

implants survival and peri-implant bone loss in

patients with uncontrolled type-2 diabetes mellitus. Curr Opin Endocrinol Diabetes Obes. 2019;26

(4):219–22.

Oikarinen K, Raustia AM, Hartikainen M. General

and local contraindications for endosseal implants ‐ an epidemiological panoramic radiograph

study in 65‐year‐old subjects. Community Dent

Oral Epidemiol. 1995;23(2):114–8.

Al Zahrani S, Al Mutairi AA. Crestal Bone Loss

Around Submerged and Non-Submerged Dental

Implants in Individuals with Type-2 Diabetes

Mellitus: A 7-Year Prospective Clinical Study. Med

Princ Pract. 2019;28(1):75–81. 19

Javed F, Romanos GE. Impact of Diabetes Mellitus and Glycemic Control on the Osseointegration

of Dental Implants: A Systematic Literature Review. J Periodontol. 2009;80(11):1719–30.

Al-Askar M, Ajlan S, Alomar N, Al-Daghri NM.

Clinical and Radiographic Peri-Implant Parameters and Whole Salivary Interleukin-1β and Interleukin-6 Levels among Type-2 Diabetic and Nondabetic Patients with and without Peri-Implantitis.

Med Princ Pract. 2018;27(2):133–8.

Rakic M, Lekovic V, Nikolic-Jakoba N, Vojvodic

D, Petkovic-Curcin A, Sanz M. Bone loss biomarkers associated with peri-implantitis. A

cross-sectional study. Clin Oral Implants Res.

;24(10):1110–6.

Abreu MH, Bianchini MA, Magini RS, Rösing CK.

Clinical and radiographic evaluation of periodontal and peri-implant conditions in patients with

implant-supported prosthesis. Acta Odontol Latinoam. 2007;20(2):87–95.

Lindhe J, Meyle J. Peri-implant diseases: Consensus Report of the Sixth European Workshop

on Periodontology. J Clin Periodontol. 2008;35

(SUPPL. 8):282–5. 16. Bessa Rebelo MA, de Queiroz AC. Gingival Indices: State of Art. Gingival Dis

- Their Aetiol Prev Treat. 2011;

Newman Takei Henry H. Klokkevold Perry R.

MG. Newman and Carranza’s Clinical Periodontology Thirteenth Edition. J Chem Inf Model.

;53(9):1689–99.

Isola G, Lo Giudice A, Polizzi A, Alibrandi A, Murabito P, Indelicato F. Identification of the different salivary Interleukin-6 profiles in patients with

periodontitis: A cross-sectional study. Arch Oral

Biol [Internet]. 2021;122(September

:104997. Available from: https://

doi.org/10.1016/j.archoralbio.2020.104997 19.

He Q, Mu Z, Shrestha A, Wang C, Wang S, Tang

H, et al. Development of a rat model for type 2

diabetes mellitus peri-implantitis: A preliminary

study. Oral Dis. 2021;(March 2020):1–11.

Radaelli K, Alberti A, Corbella S, Francetti L. The

Impact of Peri-Implantitis on Systemic Diseases

and Conditions: A Review of the Literature. Int J

Dent. 2021;2021.

He Q, Mu Z, Shrestha A, Wang C, Wang S, Tang

H, et al. Development of a rat model for type 2

diabetes mellitus peri-implantitis: A preliminary

study. Oral Dis. 2021;(March 2020):1–11. 20.

Radaelli K, Alberti A, Corbella S, Francetti L. The

Impact of Peri-Implantitis on Systemic Diseases

and Conditions: A Review of the Literature. Int J

Dent. 2021;2021.

Radaelli K, Alberti A, Corbella S, Francetti L. The

Impact of Peri-Implantitis on Systemic Diseases

and Conditions: A Review of the Literature. Int J

Dent. 2021;2021.

Zhou SY, Duan XQ, Hu R, Ouyang XY. Effect of

non-surgical periodontal therapy on serum levels

of TNF-a, IL-6 and C-reactive protein in periodontitis subjects with stable coronary heart disease.

Chin J Dent Res. 2013;16(2):145–51.

Yeh HC, Lu JJ, Chang SC, Ge MC. Identification

of microbiota in peri-implantitis pockets by matrix-assisted laser desorption/ionization time-offlight mass spectrometry. Sci Rep [Internet].

;9(1):1–9. Available from: http://

dx.doi.org/10.1038/s41598-018-37450-5

Celakovsky P, Kalfert D, Smatanova K, Tucek L,

Cermakova E, Mejzlik J, et al. Bacteriology of deep

neck infections: Analysis of 634 patients. Aust

Dent J. 2015;60(2):212–5.

Fu JH, Wang HL. Breaking the wave of periimplantitis. Periodontol 2000. 2020;84(1):145–60.

Lagunov VL, Sun J, George R. Evaluation of biologic implant success parameters in type 2 diabetic glycemic control patients versus health patients: A meta-analysis. J Investig Clin Dent.

;10(4):e12478.

Al Amri MD, Kellesarian SV, Al-Kheraif AA, Malmstrom H, Javed F, Romanos GE. Effect of oral hygiene maintenance on HbA1c levels and periimplant parameters around immediatelyloaded

dental implants placed in type-2 diabetic patients: 2 years follow-up. Clin Oral Implants Res.

;27(11):1439–43.

Alsahhaf A, Alshiddi IF, Alshagroud RS, Al-Aali

KA, Vohra F, Abduljabbar T. Clinical and radiographic indices around narrow diameter implants

placed in different glycemic-level patients. Clin

Implant Dent Relat Res. 2019;21(4):621–6.

Jepsen S, Caton JG, Albandar JM, Bissada NF,

Bouchard P, Cortellini P, et al. Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of

workgroup 3 of the 2017 World Workshop on the

Classification of Periodontal and Peri-Implant

Diseases and Conditions. J Clin Periodontol.

;45(December 2017):S219–29.

Jung CY, Kim KC, Sung YS. Ce Pt E Us Cr Ip T Pt E

Us Cr. 2019;1–24.

Sanz M, Ceriello A, Buysschaert M, Chapple I,

Demmer RT, Graziani F, et al. Scientific evidence

on the links between periodontal diseases and

diabetes: Consensus report and 21 guidelines of

the joint workshop on periodontal diseases and

diabetes by the International Diabetes Federation

and the European Federation of Periodontology. J

Clin Periodontol. 2018;45(2):138–49.

Albandar JM, Susin C, Hughes FJ. Manifestations

of systemic diseases and conditions that affect

the periodontal attachment apparatus: Case definitions and diagnostic considerations. J Clin Periodontol. 2018;45(October 2017):S171–89.

Sghaireen MG, Alduraywish AA, Chandan Srivastava K, Shrivastava D, Patil SR, Habib S Al, et al.

Comparative evaluation of dental implant failure

among healthy and well-controlled diabetic patients—a 3-year retrospective study. Int J Environ

Res Public Health. 2020;17(14):1–10.

Andrade CAS, Paz JLC, de Melo GS, Mahrouseh

N, Januário AL, Capeletti LR. Survival rate and peri

-implant evaluation of immediately loaded dental

implants in individuals with type 2 diabetes mellitus: a systematic review and meta-analysis. Clin

Oral Investig [Internet]. 2022;26(2):1797–810.

Available from: https://doi.org/10.1007/s00784-

-04154-6

Ansari Y Al, Shahwan H, Chrcanovic BR. Diabetes

Mellitus and Dental Implants: A Systematic Review and Meta-Analysis. Materials (Basel).

;15(9).

Erdogan Ö, Uçar Y, Tatli U, Sert M, Benlidayi ME,

Evlice B. A clinical prospective study on alveolar

bone augmentation and dental implant success in

patients with type 2 diabetes. Clin Oral Implants

Res. 2015;26(11):1267–75.

Downloads

Published

2023-12-22

How to Cite

1.
Hamad-Ameen RM, Omer OA-B. Impact of diabetes mellitus on dental implants: A cross sectional controlled clinical study. EDJ [Internet]. 2023 Dec. 22 [cited 2024 Nov. 23];6(2):203-14. Available from: https://edj.hmu.edu.krd/index.php/journal/article/view/239

Issue

Section

Original Articles