Efficacy of Hyaluronic Acid Injection for Temporomandibular Joint Disorders with and without Arthrocentesis
DOI:
https://doi.org/10.15218/edj.2025.2Keywords:
Temporomandibular joint disorders, Arthrocentesis, Hyaluronic acidAbstract
Temporomandibular disorder affects millions of people worldwide. Temporomandibular joint internal derangement, is a common condition. Temporomandibular joint internal derangement is a progressive disorder that begins with clicking during nor- mal opening and progresses to restricted mouth opening (closed lock). Arthrocentesis and Visco supplementation as Hyluronic acid are minimally invasive techniques that involves wash out the joint and replacement of synovial fluid by intra-articular injection of Hyaluronic Acid which restores its concentration and molecular weight in joint cavity.
Aims for this study is to comparison the effect of Hyaluronic acid injection to temporomandibular joint in addition to Arthrocentesis and without arthrocentesis, to see the effect of Hyaluronic acid injection to temporomandibular joint without arthrocentesis.
Patient and Methods: The study was prospective, randomized, and clinical, with a period of 3 months follow-up comparing the efficacy of arthrocentesis with HA injection to that of HA injection alone. The data were collected after first and third months in order to gauge the effectiveness of the treatment modality at Rizgary Teaching Hospital. It included patients from November 2023 to February 2024.
Result: A total of (60) patients 13 males and 47 females, as they distributed on three groups (Group A: 20 patients undergone Arthrocentesis and Hyaluronic acid injection, Group B1: 20 patients undergone single time Hyaluronic acid injection and Group B2: 20 patients undergone double time Hyaluronic acid injection).
P value were highly significant for pain, maximum mouth opening and joint sound for group A and B2 in compare to group B1, while there were no significant different seen between group A and B2.
Conclusion: The combination of arthrocentesis and HA injection showed much better outcome than hyaluronic acid injection alone, but procedure HA injection alone is less invasive.
References
Nitzan DW, Dolwick MF, Martinez GA. Temporomandibular joint arthrocentesis: A simplified treatment for severe, limited mouth opening. J Oral Maxillofac Surg 1991;49:1163-7; discussion 1168-70.
Israel HA. Internal derangement of the temporomandibular joint: New perspectives on an old problem. Oral Maxillofac Surg Clin North Am 2016;28:313-33.
Emshoff R, Rudisch A. Are internal derangement and osteoarthrosis linked to changes in clinical outcome measures of arthrocentesis of the temporomandibular joint? J Oral Maxillofac Surg 2003;61:1162-7; discussion 1167-70.
Guarda Nardini L, Stifano M, Brombin C, Salmaso L, Manfredini D. A one-year case series of arthrocentesis with hyaluronic acid injections for temporomandibular joint osteoarthritis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007;103:e14-22.
Thein R, Haviv B, Kidron A, Bronak S. Intra-articular injection of hyaluronic acid following arthroscopic partial meniscectomy of the knee. Orthopedics 2010;33:724.
Chandrasekaran S, Gui C, Walsh JP, Lodhia P, Suarez-Ahedo C, Domb BG. Correlation Between Changes in Visual Analog Scale and Patient-Reported Outcome Scores and Patient Satisfaction After Hip Arthroscopic Surgery. Orthop J Sports Med. 2017 Sep 13;5(9):2325967117724772.
Elfving, Lars & Helkimo, Martti & Magnusson, Tomas. (2002). Prevalence of different temporomandibular joint sounds, with emphasis on disc-displacement, in patients with temporomandibular disorders and controls. Swedish dental journal. 26. 9-19.
Soni A. Arthrocentesis of Temporomandibular Joint- Bridging the Gap Between Non-Surgical and Surgical Treatment. Ann Maxillofac Surg. 2019 Jan-Jun;9(1):158-167.
Nees TA, Rosshirt N, Zhang JA, Reiner T, Sorbi R, Tripel E, Walker T, Schiltenwolf M, Hagmann S, Moradi B. Synovial Cytokines Significantly Correlate with Osteoarthritis-Related Knee Pain and Disability: Inflammatory Mediators of Potential Clinical Relevance. J Clin Med. 2019 Aug 29;8(9):1343.
Gurung T, Singh RK, Mohammad S, Pal US, Mahdi AA, Kumar M. Efficacy of arthrocentesis versus arthrocentesis with sodium hyaluronic acid in temporomandibular joint osteoarthritis: A comparison. Natl J Maxillofac Surg. 2017 Jan-Jun;8(1):41-49. doi: 10.4103/njms.NJMS_84_16. PMID: 28761275; PMCID: PMC5512408.
De Riu G, Stimolo M, Meloni SM, Soma D, Pisano M, Sembronio S, Tullio A. Arthrocentesis and temporomandibular joint disorders: clinical and radiological results of a prospective study. Int J Dent. 2013;2013:790648. doi: 10.1155/2013/790648. Epub 2013 Nov 11. PMID: 24319462; PMCID: PMC3844254.
Alpaslan GH, Alpaslan C. Efficacy of temporomandibular joint arthrocentesis with or without injection of sodium hyaluronate in treatment of internal derangements. J Oral Maxillofac Surg 2001;59:613-8.
Dhiman NK, Jaiswara C, Hirani MS, Chauhan N, Mahajan AD, Krishnan A. Efficacy of arthrocentesis with intra-articular injection of hyaluronic acid and corticosteroid in the treatment of internal derangement of temporomandibular joint. Natl J Maxillofac Surg. 2023 Jan-Apr;14(1):93-100. doi: 10.4103/njms.njms_8_22. Epub 2023 Apr 14. PMID: 37273422; PMCID: PMC10235751.
Gonzalez-Garcia R, Rodriguez-Campo FJ, Escorial-Hernandez V, Munoz-Guerra MF, Sastre-Perez J, Naval-Gias L, et al. Complications of temporomandibular joint arthroscopy: A retrospective analytic study of 670 arthroscopic procedures. J Oral Maxillofac Surg 2006;64:1587-91.
Nagori SA, Chattopadhyay PK, Kumar S, Kamalpathey K. Custom-made mouth prop for TMJ arthrocentesis: A technical note. Oral Maxillofac Surg 2017;21:75-7.
Guarda-Nardini L, Rossi A, Arboretti R, Bonnini S, Stellini E, Manfredini D (2015) Single- or multiple-session viscosupplementation protocols for temporomandibular joint degenerative disorders: a randomized clinical trial. J Oral Rehabil 42, 521-528.
Bjørnland T, Gjærum AA, Møystad A (2007) Osteoarthritis of the temporomandibular joint: an evaluation of the effects and complications of corticosteroid injection compared with injection with sodium hyaluronate. J Oral Rehabil 34, 583-589.
Bergstrand S, Ingstad HK, Møystad A, Bjørnland T. Long-term effectiveness of arthrocentesis with and without hyaluronic acid injection for treatment of temporomandibular joint osteoarthritis. J Oral Sci. 2019 Mar 28;61(1):82-88. doi: 10.2334/josnusd.17-0423. Epub 2019 Feb 28. PMID: 30814387.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Twana Hoshyar Saleem (Author)

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
The copyright on any article published in Erbil Dental Journal is retained by the author(s) in agreement with the Creative Commons Attribution Non-Commercial ShareAlike License (CC BY-NC-SA 4.0).