Impact of Non-Surgical Periodontal Treatment on Total WBC Count in Patients with Periodontitis

Authors

  • Hozan Wrya Azeez Periodontics Department, College of Dentistry, Hawler Medical University
  • Arkhawan Ali Abdulhaq Periodontics Department, College of Dentistry, Hawler Medical University
  • Ziwar Ahmed Salih Periodontics Department, College of Dentistry, Hawler Medical University

DOI:

https://doi.org/10.15218/edj.2018.12

Keywords:

Non-surgical periodontal therapy, Total WBC counts, Clinical parameters, Chronic periodontitis, Healthy subjects

Abstract

Background and objectives: Chronic periodontitis is an inflammatory disorders associated to the accumulation of microbial biofilm and the response of host to this accumulation. In our society the importance of total WBC counts has not yet been investigated with chronic periodontitis. The objective of this study was to investigate the impact of treatment on total WBC counts in subjects with chronic periodontitis.

Materials and methods: A total of 50 subjects were selected for the study. Venous blood samples were taken at base line and 4 weeks after non-surgical periodontal therapy for the study group (group II), and one time for the control group (group I) to estimate total WBC counts. Clinical parameters such as Plaque Index, Gingival Index, probing pocket depth, the clinical attachment level for group II were measured.

Results: The result of the present study shows a highly significant decrease of total WBC counts between group I and II before treatment P value=0.004. Our results indicate that there is a highly significant decrease of Gingival Index and probing pocket depth at base line compared with after treatment P value=0.003 and 0.000 respectively. Also, a significant decrease in Plaque Index and clinical attachment level at base line and 4 weeks following therapy P value=0.035 and 0.026 respectively. In addition, a significant decrease of total WBC counts at base line and 4 weeks following therapy P value=0.016. Statistical tests were done by standard program data processing (MS excel) paired t test.

Conclusion: The present study concludes that total WBC counts were decreased after non- surgical periodontal therapy

References

References
1. Flemmig TF. Periodontitis. Annals of Periodontology. 1999; 4:32-7.
doi.org/10.1902/annals.1999.4.1.32
2. Garlet GP. Destructive and protective roles of cytokines in periodontitis: a re-appraisal from host defense and tissue destruction viewpoints. J Dent Res 2010; 89(12):1349-63.
doi.org/10.1177/0022034510376402
3. Ohlrich EJ, Cullinan MP, Seymour GJ. The immunopathogenesis of periodontal disease. Aust Dent J 2009; 54(s1). doi.org/10.1111/j.1834-7819.2009.01139.x
4. Lang NP, Schätzle MA, Löe H. Gingivitis as a risk factor in periodontal disease. J Clin Period 2009; 36(s10):3-8.
doi.org/10.1111/j.1600-051X.2009.01415.x
5. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. The Lancet. 2005; 366(9499):1809-20.
doi.org/10.1016/S0140-6736(05)67728-8
6. Dave S, Batista JE, Van TD. Cardiovascular disease and periodontal diseases: commonality and causation. Compendium of continuing education in dentistry (Jamesburg, NJ: 1995). 2004 ; 25(7 Suppl 1):26-37.
7. Agarwal S, Huang JP, Piesco NP, Suzuki JB, Riccelli AE, Johns LP. Altered neutrophil function in localized juvenile periodontitis: intrinsic or induced? J Period 1996; 67(3S):337-44.
doi.org/10.1902/jop.1996.67.3s.337
8 Loos BG. Systemic markers of inflammation in periodontitis. J Period 2005; 76:11 Suppl:2106-15.
9. Ebersole JL, Machen RL, Steffen MJ, Willmann DE. Systemic acute‐phase reactants, C‐reactive protein and haptoglobin, in adult periodontitis. Clin Exper Immun 1997; 107(2):347-52.
doi.org/10.1111/j.1365-2249.1997.270-ce1162.x
10. Pejčić A, Kesić L, Pešić Z, Mirković D, Stojanović M. White blood cell count in different stages of chronic periodontitis. Acta Clinical Croatica. 2011; 50(2):159-67.
11. Nupur A, Veerendra K, Sheela G. Effect of periodontal therapy on hemoglobin and erythrocyte levels in chronic generalized periodontitis patients: An interventional study. J Ind Soc Period 2009; 13(1):6-11.
12. Aljohani HA. Association between hemoglobin level and severity of chronic periodontitis. Med Sci 2010; 17(1).53-64.
13. Lindhe J, Niklaus P L, Karring T (2008). Clinical periodontology and implant dentistry. 5th. Blackwell publishing company: Blackwell Munksgaard.
14. Bortlod P, Ishkawa I, De Deios N (2003). Current trends in periodontal diagnosis, disease recognition and management, proceedings of the 5th Asian pacific society of periodontology meeting, Cebu. The Philippines. 1-2 December.
15. Vaishali S, Parveen S, Vishunupriya V, Gayathri R Saveetha GR. WBC Count in Patients with Chronic Periodontitis. Int J Pharm Sci Rev Res, 2016; 39(2): 16-19.
16. Kweider M, Lowe GD, Murray GD, Kinane DF, McGowan DA. Dental disease, fibrinogen and white cell count; links with myocardial infarction. Scottish Med J 1993; 38(3):73-4.
doi.org/10.1177/003693309303800304
17. Wu T, Trevisan M, Genco RJ, Falkner KL, Dorn JP, Sempos CT. Examination of the relation between periodontal health status and cardiovascular risk factors: serum total and high density lipoprotein cholesterol, C-reactive protein, and plasma fibrinogen. Am J Epidem 2000; 151(3):273-82.
doi.org/10.1093/oxfordjournals.aje.a010203
18. Gokhale ST, Sharma A, Gupta R. Effect of Non-Surgical Therapy on WBC Count in Generalised Chronic Periodontitis Patients. Int J Sci Study 2013; 1(2):36-9.
19. Christan C, Dietrich T, Hägewald S, Kage A, Bernimoulin JP. White blood cell count in generalized aggressive periodontitis after non‐surgical therapy. J Clin Period 2002; 29(3):201-6.
20. Taylor BA, Tofler GH, Carey HM, Morel-Kopp MC, Philcox S, Carter TR, Elliott MJ, Kull AD, Ward C, Schenck K. Full-mouth tooth extraction lowers systemic inflammatory and thrombotic markers of cardiovascular risk. J Dent Res 2006; 85(1):74-8.
doi.org/10.1177/154405910608500113
21. Siddeshappa ST, Nagdeve S, Yeltiwar RK,Parvez H, Deonani S, Diwan V. Evaluation of various hematological parameters in patients with periodontitis after nonsurgical therapy at different intervals. J Ind Soc Period 2016; 20(2):180.
doi: 10.4103/0972-124X.175172
22. Rai B, Anand SC. After scaling and root planing lower systemic inflammatory and thrombotic marker of cardiovascular risk. Middle-East J Sci Res 2007;2(2):54-6.
23. Joseph B, Janam P. Estimation of various red blood cell parameters in severe chronic periodontitis patients before and after nonsurgical periodontal therapy- A quasiexperimental study. Int J Res Den 2013 Jul-Aug; 3 (4):1-13.

Downloads

Published

2018-12-06

How to Cite

1.
Azeez HW, Abdulhaq AA, Salih ZA. Impact of Non-Surgical Periodontal Treatment on Total WBC Count in Patients with Periodontitis. EDJ [Internet]. 2018 Dec. 6 [cited 2024 Nov. 21];1(2):86-92. Available from: https://edj.hmu.edu.krd/index.php/journal/article/view/38

Issue

Vol. 1 No. 2 (2018): EDJ

Section

Original Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The copyright on any article published in Erbil Dental Journal is retained by the author(s) in agreement with the Creative Commons Attribution Non-Commercial ShareAlike License (CC BY-NC-SA 4.0).